2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00033
    Iomazenil 127985-21-1 98%
    Iomazenil is a benzodiazepine receptor antagonist with partial inverse agonist activity. Iomazenil can assess the binding potential of central benzodiazepine receptors in the cerebral cortex and may reflect neuronal function in viable tissue. Iomazenil use is associated with improved cognitive function in adult patients with ischemic cerebral pathology after indirect revascularization surgery. Iomazenil demonstrated restoration of benzodiazepine receptor binding potential in the affected hemisphere after surgery on brain SPECT imaging.
    Iomazenil
  • HY-U00049
    Mioflazine 79467-23-5 98%
    Mioflazine is an orally active nucleoside transport inhibitor with sleep-improving activity. Mioflazine significantly improves cardiac survival after global cardiac ischemia. Mioflazine inhibits nucleoside uptake Mioflazine does not exhibit inotropic effects during induction and nursing.
    Mioflazine
  • HY-U00051
    Propiomazine 362-29-8 98.91%
    Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia.
    Propiomazine
  • HY-U00432
    S-MTC 156719-41-4 98%
    S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.
    S-MTC
  • HY-Y0055S
    Phenothiazine-d8 1219803-41-4 99.0%
    Phenothiazine-d8 is the deuterium labeled Phenothiazine. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
    Phenothiazine-d8
  • HY-Y0061R
    Oxindole (Standard) 59-48-3
    Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
    Oxindole (Standard)
  • HY-Y0135R
    Tropinone (Standard) 532-24-1
    Tropinone (Standard) is the analytical standard of Tropinone. This product is intended for research and analytical applications. Tropinone, an alkaloid, acts as a synthetic intermediate to Atropine.
    Tropinone (Standard)
  • HY-Y0148R
    10-Hydroxydecanoic acid (Standard) 1679-53-4
    10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].
    10-Hydroxydecanoic acid (Standard)
  • HY-Y0258S
    Benzocaine-d4 342611-08-9 98%
    Benzocaine-d4 is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
    Benzocaine-d4
  • HY-Y0265R
    Isatin (Standard) 91-56-5
    Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system.
    Isatin (Standard)
  • HY-Y0304R
    Dibutyl phthalate (Standard) 84-74-2
    Dibutyl phthalate (Standard) is the analytical standard of Dibutyl phthalate. This product is intended for research and analytical applications. Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications. May cause toxicity and adverse neurobehavioral effects.
    Dibutyl phthalate (Standard)
  • HY-Y0378R
    D-Leucine (Standard) 328-38-1
    D-Leucine (Standard) is the analytical standard of D-Leucine. This product is intended for research and analytical applications. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.
    D-Leucine (Standard)
  • HY-Y0399S
    L-Norvaline-d5 1202936-50-2 98%
    L-Norvaline-d5 is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.
    L-Norvaline-d5
  • HY-Y0682R
    Ethylenediaminetetraacetic acid (Standard) 60-00-4
    Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[4].
    Ethylenediaminetetraacetic acid (Standard)
  • HY-Y0921R
    (±)-1,2-Propanediol (Standard) 57-55-6
    (±)-1,2-Propanediol (Standard) is the analytical standard of (±)-1,2-Propanediol. This product is intended for research and analytical applications. (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.
    (±)-1,2-Propanediol (Standard)
  • HY-Y0921S
    (±)-1,2-Propanediol-d8 80156-55-4 98%
    (±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d8
  • HY-Y1176S
    Isonipecotic acid-d9 1219798-43-2 98%
    Isonipecotic acid-d9 is the deuterium labeled Isonipecotic acid. Isonipecotic acid is a GABAA receptor partial agonist.
    Isonipecotic acid-d9
  • HY-Y1373R
    Cyclohexanecarboxylic acid (Standard) 98-89-5
    Cyclohexanecarboxylic acid (Standard) is the analytical standard of Cyclohexanecarboxylic acid. This product is intended for research and analytical applications. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid (Standard)
  • HY-Y1373S
    Cyclohexanecarboxylic acid-d1 933-37-9 98%
    Cyclohexanecarboxylic acid-d1 is the deuterium labeled Cyclohexanecarboxylic acid. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid-d1
  • HY-100046R
    Nordoxepin hydrochloride (Standard) 2887-91-4
    Nordoxepin (hydrochloride) (Standard) is the analytical standard of Nordoxepin (hydrochloride). This product is intended for research and analytical applications. Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression.
    Nordoxepin hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity